Quick rule of thumb for mastery evaluation : if it has a hard number (like +10 health per mastery) then it isn't worth it. % increases are much better as they scale with your bots power. For example the first options in both defense and offense. Don't put more than 1 point in.
Also look at how much level 2 increases vs level 1. Some masteries have a first level of like a 8% increase or whatever and then the next 4 levels are 2% increases, but more expensive. Consider just taking 1 there for more bang for buck if you're interested in the effect. Like this one:
And for the rest ... as you get better and better at not getting hit, go for more offensive options over defense. End the fight quicker also means less damage done to you.
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P2W ninja mastery
Also look at how much level 2 increases vs level 1. Some masteries have a first level of like a 8% increase or whatever and then the next 4 levels are 2% increases, but more expensive. Consider just taking 1 there for more bang for buck if you're interested in the effect. Like this one:
And for the rest ... as you get better and better at not getting hit, go for more offensive options over defense. End the fight quicker also means less damage done to you.
How did you unlock the gold bleed?
Despair level 1
10 OFFENSIVE Points spent
And the Tier 2 Mastery Cores from the Mastery Store.